Open AccessPenetrance of Functioning and Nonfunctioning Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1 in the Second Decade of Life
Author(s) -
Tatiana Denck Gonçalves,
Rodrigo A. Toledo,
Tomoko Sekiya,
Sérgio E. Matuguma,
Fauze MalufFilho,
Manoel de Souza Rocha,
Sheila Aparecida Coelho Siqueira,
Andréa Glezer,
Marcelo D. Bronstein,
Maria Adelaide A. Pereira,
Ricardo Jureidini,
Telésforo Bacchella,
Marcel Cerqueira César Machado,
S. P. A. Toledo,
Delmar Muniz Lourenço
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-1768
Subject(s) - men1 , multiple endocrine neoplasia , gastrinoma , medicine , insulinoma , penetrance , neuroendocrine tumors , malignancy , radiology , magnetic resonance imaging , endocrine system , pathology , gastroenterology , pancreas , biology , gene , biochemistry , secretion , hormone , gastrin , phenotype
Data are scarce on the penetrance of multiple endocrine neoplasia type 1 (MEN1)-related nonfunctioning pancreatic neuroendocrine tumors (NF-PETs) and insulinomas in young MEN1 patients. A potential positive correlation between tumor size and malignancy (2-3 cm, 18%; >3 cm, 43%) has greatly influenced the management of MEN1 adults with NF-PETs.
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