Open AccessIncreasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54
Author(s) -
Chan. Jayasena,
Ali Abbara,
Johannes D. Veldhuis,
Alexander Comninos,
Risheka Ratnasabapathy,
Akila De Silva,
Gurjinder Nijher,
Zainab GaniyuDada,
Amrish Mehta,
Catriona Todd,
Mohammad A. Ghatei,
Stephen R. Bloom,
Waljit S. Dhillo
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-1569
Subject(s) - kisspeptin , endocrinology , medicine , pulsatile flow , luteinizing hormone , amenorrhea , gonadotropin releasing hormone , gonadotropin , hypothalamus , hormone , biology , pregnancy , genetics
Hypothalamic amenorrhea (HA) is the one of the most common causes of period loss in women of reproductive age and is associated with deficient LH pulsatility. High-dose kisspeptin-54 acutely stimulates LH secretion in women with HA, but chronic administration causes desensitization. GnRH has paradoxical effects on reproductive activity; we therefore hypothesized that a dose-dependent therapeutic window exists within which kisspeptin treatment restores the GnRH/LH pulsatility in women with HA.
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