Open AccessCirculating Levels of FGF-21 in Obese Youth: Associations With Liver Fat Content and Markers of Liver Damage
Author(s) -
Cosimo Giannini,
Ariel E. Feldstein,
Nicola Santoro,
Grace Kim,
Romy Kursawe,
Bridget Pierpont,
Sonia Caprio
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-1250
Subject(s) - medicine , endocrinology , fgf21 , fatty liver , insulin , liver biopsy , nonalcoholic fatty liver disease , cytokeratin , obesity , steatohepatitis , biopsy , fibroblast growth factor , disease , immunohistochemistry , receptor
Fibroblast growth factor (FGF)-21 is highly expressed in the liver and regulates glucose and lipid metabolism in rodents. The effects of obesity and fatty liver on circulating FGF-21 levels have been described mainly in adults. Herein, we measured plasma FGF-21 levels in lean and obese adolescents with low and high hepatic fat content (HFF% <5.5% and HFF% ≥ 5.5%, respectively) and explored their relationship with hepatic fat content, measures of hepatic apoptosis, and insulin sensitivity.
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