Open AccessGenetic Variation in NR1H4 Encoding the Bile Acid Receptor FXR Determines Fasting Glucose and Free Fatty Acid Levels in Humans
Author(s) -
Martin Heni,
Róbert Wágner,
Caroline Ketterer,
Anja Böhm,
Katarzyna Linder,
Fausto Machicao,
Jürgen Machann,
Fritz Schick,
Anita M. Hennige,
Norbert Stefan,
HansUlrich Häring,
Andreas Fritsche,
Harald Staiger
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-1177
Subject(s) - medicine , endocrinology , farnesoid x receptor , single nucleotide polymorphism , biology , bile acid , carbohydrate metabolism , lipid metabolism , steatosis , type 2 diabetes , fatty acid , insulin , diabetes mellitus , genotype , genetics , gene , biochemistry , nuclear receptor , transcription factor
Bile acid signaling via farnesoid X receptor (FXR) regulates glucose and lipid levels, fat mass, and hepatic steatosis in animal models.
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