Open AccessPlasma Levels of Advanced Glycation Endproducts Nϵ-(carboxymethyl)lysine, Nϵ-(carboxyethyl)lysine, and Pentosidine Are not Independently Associated With Cardiovascular Disease in Individuals With or Without Type 2 Diabetes: The Hoorn and CODAM Studies
Author(s) -
Nordin M.J. Hanssen,
Lian Engelen,
Isabel Ferreira,
Jean L.J.M. Scheijen,
M. Huijberts,
Marleen M. J. van Greevenbroek,
Carla Kallen,
Joost Dekker,
Giel Nijpels,
Coen D.A. Stehouwer,
Casper G. Schalkwijk
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-1068
Subject(s) - pentosidine , glycation , lysine , advanced glycation end product , medicine , endocrinology , interquartile range , diabetes mellitus , metabolism , confounding , carbohydrate metabolism , cohort , chemistry , biochemistry , amino acid
Experimental and histological data suggest a role for advanced glycation end products (AGEs) in cardiovascular disease (CVD), particularly in type 2 diabetes (T2DM). However, the epidemiological evidence of an adverse association between AGEs and CVD remains inconclusive. We therefore investigated, in individuals with various degrees of glucose metabolism, the associations of plasma AGEs with prevalent CVD.
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