Critical Role of Histone Acetylation by p300 in Human Placental 11β-HSD2 Expression | Zendy

Jianneng Li | Zendy; Wangsheng Wang | Zendy; Chao Liu | Zendy; Weihua Wang | Zendy; Wenjiao Li | Zendy; Qun Shu | Zendy; ZiJiang Chen | Zendy; Kang Sun | Zendy

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Critical Role of Histone Acetylation by p300 in Human Placental 11β-HSD2 Expression

Author(s) -

Jianneng Li,

Wangsheng Wang,

Chao Liu,

Weihua Wang,

Wenjiao Li,

Qun Shu,

ZiJiang Chen,

Kang Sun

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-4291

Subject(s) - syncytiotrophoblasts , chromatin immunoprecipitation , gene knockdown , acetylation , histone , immunoprecipitation , biology , hdac4 , p300 cbp transcription factors , sap30 , microbiology and biotechnology , transcription factor , histone h3 , placenta , histone h2a , gene expression , biochemistry , promoter , histone acetyltransferases , fetus , genetics , apoptosis , gene , pregnancy

Fetal overexposure to glucocorticoids leads to growth restriction. Optimal fetal glucocorticoid level is ensured by the expression of cortisol-inactivating enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in placental syncytiotrophoblasts. The transcription factor selective promoter factor 1 (Sp1) is known to up-regulate 11β-HSD2 expression in the presence of enhanced histone acetylation in syncytiotrophoblasts, but the mechanisms underlying histone acetylation remain unknown.

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