The Rise of Soluble TWEAK Levels in Severely Obese Subjects After Bariatric Surgery May Affect Adipocyte-Cytokine Production Induced by TNFα | Zendy

Elsa MaymóMasip | Zendy; Sonia FernándezVeledo | Zendy; Antonio Garcı́a-España | Zendy; Ana VázquezCarballo | Zendy; Francisco J. Tinahones | Zendy; Eduardo GarcíaFuentes | Zendy; Lourdes Garrifo-Sanchez | Zendy; Maria del Mar Rodríguez | Zendy; Joan Vendrell | Zendy; Matilde R. Chacón | Zendy

Open Access

The Rise of Soluble TWEAK Levels in Severely Obese Subjects After Bariatric Surgery May Affect Adipocyte-Cytokine Production Induced by TNFα

Author(s) -

Elsa MaymóMasip,

Sonia FernándezVeledo,

Antonio Garcı́a-España,

Ana VázquezCarballo,

Francisco J. Tinahones,

Eduardo GarcíaFuentes,

Lourdes Garrifo-Sanchez,

Maria del Mar Rodríguez,

Joan Vendrell,

Matilde R. Chacón

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-4177

Subject(s) - medicine , tumor necrosis factor alpha , adipose tissue , endocrinology , proinflammatory cytokine , cytokine , adipocyte , immunology , inflammation

Soluble TNF-like weak inducer of apoptosis (sTWEAK) is generated by the intracellular proteolytic cleavage of full-length membrane-bound TNF-like weak inducer of apoptosis (mTWEAK). sTWEAK levels are reduced in diseases with an inflammatory component. Additionally, sTWEAK hampers TNFα activity in human cells.

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