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Pediatric obesity is associated with endothelial dysfunction and hypoadiponectinemia, but the relationship between these two conditions remains to be fully clarified. Whether enhanced release of endothelin-1 (ET-1) may directly impair adiponectin (Ad) production in obese children is not known.

Elevated Endothelin-1 (ET-1) Levels May Contribute to Hypoadiponectinemia in Childhood Obesity