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Aquaporin-1 Plays a Crucial Role in Estrogen-Induced Tubulogenesis of Vascular Endothelial Cells
Author(s) -
Libo Zou,
Shuai Shi,
Runju Zhang,
Tingting Wang,
YaJing Tan,
Dan Zhang,
Xiao-Yang Fei,
Guolian Ding,
Qian Gao,
Chen Cheng,
Xiao Hu,
HeFeng Huang,
JianZhong Sheng
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2012-4081
Subject(s) - ezrin , aquaporin 1 , angiogenesis , biology , gene knockdown , moesin , chromatin immunoprecipitation , estrogen , microbiology and biotechnology , cancer research , gene expression , endocrinology , promoter , cell culture , cell , gene , cytoskeleton , mechanical engineering , biochemistry , genetics , water channel , engineering , inlet
Aquaporin-1 (AQP1) has been proposed as a mediator of estrogen-induced angiogenesis in human breast cancer and endometrial cancer. Elucidation of the molecular mechanisms governing AQP1-mediated, estrogen-induced angiogenesis may contribute to an improved understanding of tumor development.

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