Low-dose Fluoride in Postmenopausal Women: A Randomized Controlled Trial | Zendy

Andrew Grey | Zendy; Sanjay Garg | Zendy; Michael Dray | Zendy; Lauren Purvis | Zendy; Anne Horne | Zendy; Karen E. Callon | Zendy; Greg Gamble | Zendy; Mark J Bolland | Zendy; Ian R. Reid | Zendy; Tim Cundy | Zendy

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Low-dose Fluoride in Postmenopausal Women: A Randomized Controlled Trial

Author(s) -

Andrew Grey,

Sanjay Garg,

Michael Dray,

Lauren Purvis,

Anne Horne,

Karen E. Callon,

Greg Gamble,

Mark J Bolland,

Ian R. Reid,

Tim Cundy

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-4062

Subject(s) - randomized controlled trial , fluoride , postmenopausal women , medicine , chemistry , inorganic chemistry

Trials of high-dose fluoride have reported increased bone formation and bone mineral density (BMD), but impaired bone mineralization and either adverse or neutral effects on fracture risk. Meta-analysis of a heterogeneous dataset of small trials suggests that daily doses of <20 mg fluoride might reduce fracture risk, but it is not known whether low doses of fluoride are safely anabolic to bone.

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