Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men | Zendy

Claes Ohlsson | Zendy; Maria Nilsson | Zendy; Åsa Tivesten | Zendy; Henrik Ryberg | Zendy; Dan Mellström | Zendy; Magnus K. Karlsson | Zendy; Östen Ljunggren | Zendy; Fernand Labrie | Zendy; Eric Orwoll | Zendy; David M. Lee | Zendy; Stephen R. Pye | Zendy; Terence W O’Neill | Zendy; Joseph D. Finn | Zendy; Judith E. Adams | Zendy; Kate A. Ward | Zendy; Steven Boonen | Zendy; György Bártfai | Zendy; Felipe F. Casanueva | Zendy; Gianni Forti | Zendy; Aleksander Giwercman | Zendy; Thang S. Han | Zendy; Ilpo Huhtaniemi | Zendy; Krzysztof Kula | Zendy; Michael E. J. Lean | Zendy; Neil Pendleton | Zendy; Margus Punab | Zendy; Dirk Vanderschueren | Zendy; Frederick C. W. Wu | Zendy; Liesbeth Vandenput | Zendy

Open Access

Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men

Author(s) -

Claes Ohlsson,

Maria Nilsson,

Åsa Tivesten,

Henrik Ryberg,

Dan Mellström,

Magnus K. Karlsson,

Östen Ljunggren,

Fernand Labrie,

Eric Orwoll,

David M. Lee,

Stephen R. Pye,

Terence W O’Neill,

Joseph D. Finn,

Judith E. Adams,

Kate A. Ward,

Steven Boonen,

György Bártfai,

Felipe F. Casanueva,

Gianni Forti,

Aleksander Giwercman,

Thang S. Han,

Ilpo Huhtaniemi,

Krzysztof Kula,

Michael E. J. Lean,

Neil Pendleton,

Margus Punab,

Dirk Vanderschueren,

Frederick C. W. Wu,

Liesbeth Vandenput

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3861

Subject(s) - immunoassay , medicine , radioimmunoassay , body mass index , context (archaeology) , osteoporosis , chemiluminescent immunoassay , endocrinology , immunology , antibody , biology , paleontology

Immunoassay-based techniques, routinely used to measure serum estradiol (E2), are known to have reduced specificity, especially at lower concentrations, when compared with the gold standard technique of mass spectrometry (MS). Different measurement techniques may be responsible for the conflicting results of associations between serum E2 and clinical phenotypes in men.

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