Theca-Derived BMP4 and BMP7 Down-Regulate Connexin43 Expression and Decrease Gap Junction Intercellular Communication Activity in Immortalized Human Granulosa Cells | Zendy

HsunMing Chang | Zendy; JungChien Cheng | Zendy; Peter C. K. Leung | Zendy

Open Access

Theca-Derived BMP4 and BMP7 Down-Regulate Connexin43 Expression and Decrease Gap Junction Intercellular Communication Activity in Immortalized Human Granulosa Cells

Author(s) -

HsunMing Chang,

JungChien Cheng,

Peter C. K. Leung

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3851

Subject(s) - microbiology and biotechnology , bone morphogenetic protein 7 , smad , bone morphogenetic protein 4 , gene knockdown , gap junction , bone morphogenetic protein , biology , small interfering rna , granulosa cell , intracellular , downregulation and upregulation , smad2 protein , cell culture , chemistry , endocrinology , signal transduction , transfection , follicular phase , gene , biochemistry , genetics

Connexin43 (Cx43)-coupled gap junctions in granulosa cells play important roles in follicular and oocyte development and may be modulated by theca cell-derived bone morphogenic protein (BMP) 4 and BMP7.

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