Overexpression of Integrin-β1 in Leiomyoma Promotes Cell Spreading and Proliferation | Zendy

Hsiu-Mei Chen | Zendy; Yi-Hsuan Lin | Zendy; Ya-Min Cheng | Zendy; Lih-Yuh C. Wing | Zendy; ShawJenq Tsai | Zendy

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Overexpression of Integrin-β1 in Leiomyoma Promotes Cell Spreading and Proliferation

Author(s) -

Hsiu-Mei Chen,

Yi-Hsuan Lin,

Ya-Min Cheng,

Lih-Yuh C. Wing,

ShawJenq Tsai

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3647

Subject(s) - integrin , disintegrin , focal adhesion , microbiology and biotechnology , cell adhesion , extracellular matrix , paxillin , cell growth , biology , fibronectin , ptk2 , collagen receptor , cell migration , signal transduction , cell , matrix metalloproteinase , metalloproteinase , biochemistry , mitogen activated protein kinase kinase , protein kinase c

Uterine leiomyoma, the most common tumors found in the women of the reproductive age, may cause abnormal uterine bleeding and be life threatening. Compared with myometrium, leiomyoma contains excessive extracellular matrix (ECM). However, the pathological roles of ECM in the development of leiomyoma remain largely unknown. Integrins are the major adhesion molecules on cell surface to interact with ECM. The interactions of ECM with integrins regulate cell adhesion and initiate signals for cell growth, differentiation, and migration.

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