Manipulation of PBF/PTTG1IP Phosphorylation Status; a Potential New Therapeutic Strategy for Improving Radioiodine Uptake in Thyroid and Other Tumors | Zendy

Vicki E. Smith | Zendy; Neil Sharma | Zendy; Rachel Watkins | Zendy; Martin L. Read | Zendy; Gemma A. Ryan | Zendy; Perkin Kwan | Zendy; A Martin | Zendy; John Watkinson | Zendy; Kristien Boelaert | Zendy; J. A. Franklyn | Zendy; Christopher J. McCabe | Zendy

Open Access

Manipulation of PBF/PTTG1IP Phosphorylation Status; a Potential New Therapeutic Strategy for Improving Radioiodine Uptake in Thyroid and Other Tumors

Author(s) -

Vicki E. Smith,

Neil Sharma,

Rachel Watkins,

Martin L. Read,

Gemma A. Ryan,

Perkin Kwan,

A Martin,

John Watkinson,

Kristien Boelaert,

J. A. Franklyn,

Christopher J. McCabe

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3640

Subject(s) - cancer research , radioiodine therapy , thyroid , thyroid cancer , medicine , phosphorylation , chemistry , oncology , biochemistry

The clinical effectiveness of ablative radioiodine treatment of thyroid tumors is limited by the availability of the sodium iodide symporter (NIS) at the plasma membrane (PM) for uptake of ¹³¹I. A significant proportion of well-differentiated thyroid tumors are unable to concentrate sufficient radioiodine for effective therapy, and in other tumor models such as breast tumors, where radioiodine uptake would be an attractive therapeutic option, uptake is insufficient.

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