β-Cell Lipotoxicity After an Overnight Intravenous Lipid Challenge and Free Fatty Acid Elevation in African American Versus American White Overweight/Obese Adolescents | Zendy

Kara S. Hughan | Zendy; Riccardo C. Bonadonna | Zendy; SoJung Lee | Zendy; Sara F. Michaliszyn | Zendy; Silva Arslanian | Zendy

Open Access

β-Cell Lipotoxicity After an Overnight Intravenous Lipid Challenge and Free Fatty Acid Elevation in African American Versus American White Overweight/Obese Adolescents

Author(s) -

Kara S. Hughan,

Riccardo C. Bonadonna,

SoJung Lee,

Sara F. Michaliszyn,

Silva Arslanian

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3492

Subject(s) - medicine , endocrinology , lipotoxicity , insulin , overweight , insulin resistance , pancreatic hormone , body mass index , chemistry

Overweight/obese (OW/OB) African American (AA) adolescents have a more diabetogenic insulin secretion/sensitivity pattern compared with their American white (AW) peers. The present study investigated β-cell lipotoxicity to test whether increased free fatty acid (FFA) levels result in greater β-cell dysfunction in AA vs AW OW/OB adolescents.

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