Interleukin-4 and Prostaglandin E2 Synergistically Up-Regulate 3β-Hydroxysteroid Dehydrogenase Type 2 in Endometrioma Stromal Cells | Zendy

Yoko Urata | Zendy; Yutaka Osuga | Zendy; Ikumi Akiyama | Zendy; Miwako Nagai | Zendy; Gentaro Izumi | Zendy; Masashi Takamura | Zendy; Akiko Hasegawa | Zendy; Miyuki Harada | Zendy; Tetsuya Hirata | Zendy; Yasushi Hirota | Zendy; Osamu Yoshino | Zendy; Kaori Koga | Zendy; Shiro Kōzuma | Zendy

Open Access

Interleukin-4 and Prostaglandin E2 Synergistically Up-Regulate 3β-Hydroxysteroid Dehydrogenase Type 2 in Endometrioma Stromal Cells

Author(s) -

Yoko Urata,

Yutaka Osuga,

Ikumi Akiyama,

Miwako Nagai,

Gentaro Izumi,

Masashi Takamura,

Akiko Hasegawa,

Miyuki Harada,

Tetsuya Hirata,

Yasushi Hirota,

Osamu Yoshino,

Kaori Koga,

Shiro Kōzuma

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3475

Subject(s) - aromatase , androstenedione , medicine , endocrinology , prostaglandin e2 , estrone , biology , stromal cell , estrogen , chemistry , androgen , cancer , breast cancer , hormone

Endometriosis is a chronic inflammatory disease in which immune response and production of estrogen in endometriotic tissues are involved in the development of the disease. Prostaglandin E2 (PGE2) stimulates aromatase (P450arom) expression in endometrioma stromal cells (ESCs) and increases the production of estrogens. On the other hand, an accumulating amount of evidence suggests that IL-4, a typical Th2 cytokine, plays important roles in the disease.

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