Resveratrol Potentiates Effect of Simvastatin on Inhibition of Mevalonate Pathway in Human Endometrial Stromal Cells
Author(s) -
Jesus A. Villanueva,
Anna Sokalska,
Amanda B. Cress,
Israel Ortega,
Kaylon L. BrunerTran,
Kevin G. Osteen,
Antoni J. Dulęba
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2012-3387
Subject(s) - simvastatin , resveratrol , hmg coa reductase , reductase , mevalonic acid , mevalonate pathway , endocrinology , geranylgeranyl pyrophosphate , biology , cholesterol , biochemistry , medicine , hydroxymethylglutaryl coa reductase , biosynthesis , chemistry , enzyme
Growth of endometriotic lesions in rodent model of endometriosis is inhibited by resveratrol, a natural polyphenol with antiproliferative and antiinflammatory properties, and simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) activity.
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