No Difference in Glycosphingolipid Metabolism and Mitochondrial Function in Glucocorticoid-Induced Insulin Resistance in Healthy Men | Zendy

M. Brands | Zendy; Daniël H. van Raalte | Zendy; Maria J. Ferraz | Zendy; H. P. Sauerwein | Zendy; A. J. Verhoeven | Zendy; Johannes M. F. G. Aerts | Zendy; M. Diamant | Zendy; Mireille J. Serlie | Zendy

Open Access

No Difference in Glycosphingolipid Metabolism and Mitochondrial Function in Glucocorticoid-Induced Insulin Resistance in Healthy Men

Author(s) -

M. Brands,

Daniël H. van Raalte,

Maria J. Ferraz,

H. P. Sauerwein,

A. J. Verhoeven,

Johannes M. F. G. Aerts,

M. Diamant,

Mireille J. Serlie

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3266

Subject(s) - insulin resistance , glucocorticoid , glycosphingolipid , medicine , endocrinology , metabolism , function (biology) , chemistry , insulin , biology , biochemistry , microbiology and biotechnology

Glucocorticoids (GCs) are well known to induce insulin resistance; however, mechanisms that cause the impairement of the insulin signaling pathway have not yet been identified. In this study we measured whether GC-induced insulin resistance in humans is related to changes in muscle ceramide, GM3, and muscle mitochondrial function.

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