Peak Incidence of Pheochromocytoma and Primary Hyperparathyroidism in Multiple Endocrine Neoplasia 2: Need for Age-Adjusted Biochemical Screening | Zendy

Andreas Machens | Zendy; Kerstin Lorenz | Zendy; Henning Dralle | Zendy

Open Access

Peak Incidence of Pheochromocytoma and Primary Hyperparathyroidism in Multiple Endocrine Neoplasia 2: Need for Age-Adjusted Biochemical Screening

Author(s) -

Andreas Machens,

Kerstin Lorenz,

Henning Dralle

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3192

Subject(s) - primary hyperparathyroidism , pheochromocytoma , incidence (geometry) , multiple endocrine neoplasia , medicine , endocrine system , hyperparathyroidism , endocrinology , urology , gastroenterology , biology , hormone , mathematics , biochemistry , geometry , gene

In multiple endocrine neoplasia type 2, American Thyroid Association (ATA) management guidelines recommend continuous biochemical screening for pheochromocytoma and/or primary hyperparathyroidism. This implicit assumption of linear tumor development is difficult to reconcile with current thinking that cells accrue somatic mutations stochastically, yielding a bell-shaped distribution.

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