Circulating Growth Arrest-Specific 6 Protein Is Associated With Adiposity, Systemic Inflammation, and Insulin Resistance Among Overweight and Obese Adolescents | Zendy

FoneChing Hsiao | Zendy; YuhFeng Lin | Zendy; Po-Shiuan Hsieh | Zendy; NainFeng Chu | Zendy; YiShing Shieh | Zendy; ChangHsun Hsieh | Zendy; ChienHsing Lee | Zendy; Yi-Jen Hung | Zendy

Open Access

Circulating Growth Arrest-Specific 6 Protein Is Associated With Adiposity, Systemic Inflammation, and Insulin Resistance Among Overweight and Obese Adolescents

Author(s) -

FoneChing Hsiao,

YuhFeng Lin,

Po-Shiuan Hsieh,

NainFeng Chu,

YiShing Shieh,

ChangHsun Hsieh,

ChienHsing Lee,

Yi-Jen Hung

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3179

Subject(s) - medicine , gas6 , endocrinology , insulin resistance , overweight , waist , body mass index , systemic inflammation , obesity , inflammation , receptor , receptor tyrosine kinase

Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Preclinical studies indicate that Gas6 and its receptors of the TAM (Tyro-3, Axl, Mer) family may be involved in the pathogenesis of obesity and its complications, including systemic inflammation and insulin resistance. Until now, little has been known about the clinical significance of the Gas6/TAM system in childhood obesity.

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