Plasma Dickkopf1 (DKK1) Concentrations Negatively Associate with Atherosclerotic Calcified Plaque in African-Americans with Type 2 Diabetes | Zendy

Thomas C. Register | Zendy; Keith A. Hruska | Zendy; Jasmin Divers | Zendy; Donald W. Bowden | Zendy; Nicholette D. Palmer | Zendy; J. Jeffrey Carr | Zendy; Lynne E. Wagenknecht | Zendy; R. Caresse Hightower | Zendy; Jianzhao Xu | Zendy; S. Carrie Smith | Zendy; Dennis J. Dietzen | Zendy; Carl D. Langefeld | Zendy; Barry I. Freedman | Zendy

Open Access

Plasma Dickkopf1 (DKK1) Concentrations Negatively Associate with Atherosclerotic Calcified Plaque in African-Americans with Type 2 Diabetes

Author(s) -

Thomas C. Register,

Keith A. Hruska,

Jasmin Divers,

Donald W. Bowden,

Nicholette D. Palmer,

J. Jeffrey Carr,

Lynne E. Wagenknecht,

R. Caresse Hightower,

Jianzhao Xu,

S. Carrie Smith,

Dennis J. Dietzen,

Carl D. Langefeld,

Barry I. Freedman

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3038

Subject(s) - medicine , cardiology , bone mineral , body mass index , endocrinology , diabetes mellitus , type 2 diabetes , artery , coronary artery disease , osteoporosis

Bone mineral density (BMD) and atherosclerotic arterial calcified plaque (CP) demonstrate inverse relationships through unknown mechanisms. Dickkopf-1 (DKK1) is an endogenous inhibitor of bone formation, and serum DKK1 has been associated with impaired osteoblast activation and susceptibility to bone loss. Plasma DKK1, BMD in the spine, and CP in three arterial beds were assessed in African-Americans (AAs) to determine relationships of serum DKK1 with atherosclerotic vascular calcification.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research