The Role of Pigment Epithelium-Derived Factor in the Pathophysiology and Treatment of Ovarian Hyperstimulation Syndrome in Mice | Zendy

Dana Chuderland | Zendy; Ido BenAmi | Zendy; Ruth KaplanKraicer | Zendy; Hadas Grossman | Zendy; Raphaël Ron-El | Zendy; Ruth Shalgi | Zendy

Open Access

The Role of Pigment Epithelium-Derived Factor in the Pathophysiology and Treatment of Ovarian Hyperstimulation Syndrome in Mice

Author(s) -

Dana Chuderland,

Ido BenAmi,

Ruth KaplanKraicer,

Hadas Grossman,

Raphaël Ron-El,

Ruth Shalgi

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3037

Subject(s) - pedf , ovarian hyperstimulation syndrome , vascular endothelial growth factor , endocrinology , medicine , vascular permeability , pathophysiology , edema , vascular endothelial growth factor a , angiogenesis , biology , in vitro fertilisation , embryo , vegf receptors , microbiology and biotechnology

Ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening complication of assisted reproduction. OHSS is induced by an ovarian release of vasoactive, angiogenic substances that results in vascular hyperpermeability, leakage, and shift of fluids from blood vessels into the extravascular space with consequent ascites and edema that are attributed to vascular endothelial growth factor (VEGF).

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