Experimental Hyperleptinemia Acutely Increases Vasoconstrictory Sympathetic Nerve Activity in Healthy Humans | Zendy

Felix Machleidt | Zendy; Paul Simon | Zendy; Alexander F. Krapalis | Zendy; Manfred Hallschmid | Zendy; Hendrik Lehnert | Zendy; Friedhelm Sayk | Zendy

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Experimental Hyperleptinemia Acutely Increases Vasoconstrictory Sympathetic Nerve Activity in Healthy Humans

Author(s) -

Felix Machleidt,

Paul Simon,

Alexander F. Krapalis,

Manfred Hallschmid,

Hendrik Lehnert,

Friedhelm Sayk

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-3009

Subject(s) - blood pressure , leptin , medicine , sympathetic nervous system , placebo , heart rate , microneurography , endocrinology , obesity , cardiology , baroreflex , alternative medicine , pathology

Obesity and arterial hypertension are tightly connected. Obese individuals show significant elevation of vasoconstrictory muscle sympathetic nerve activity (MSNA). Obesity-related hyperleptinemia might play a key role in mediating these effects. Leptin is synthesized in proportion to body fat mass and activates SNA in animal models. In humans, however, direct evidence linking hyperleptinemia to sympathetic activation has not yet been established. In the present study, we characterize the effects of acute hyperleptinemia on microneurographically recorded SNA in humans.

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