Identification of a CpG Island Methylator Phenotype in Adrenocortical Carcinomas | Zendy

Olivia Barreau | Zendy; Guillaume Assié | Zendy; H. Wilmot-Roussel | Zendy; Bruno Ragazzon | Zendy; Camille Baudry | Zendy; Karine Perlemoine | Zendy; Fernande René-Corail | Zendy; Xavier Bertagna | Zendy; B. Dousset | Zendy; Nadim Hamzaoui | Zendy; Frédérique Tissier | Zendy; Aurélien de Reyniès | Zendy; Jérôme Bertherat | Zendy

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Identification of a CpG Island Methylator Phenotype in Adrenocortical Carcinomas

Author(s) -

Olivia Barreau,

Guillaume Assié,

H. Wilmot-Roussel,

Bruno Ragazzon,

Camille Baudry,

Karine Perlemoine,

Fernande René-Corail,

Xavier Bertagna,

B. Dousset,

Nadim Hamzaoui,

Frédérique Tissier,

Aurélien de Reyniès,

Jérôme Bertherat

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2993

Subject(s) - dna methylation , methylation , cpg site , biology , adrenocortical carcinoma , cancer research , microsatellite instability , microbiology and biotechnology , gene , genetics , gene expression , microsatellite , allele , endocrinology

DNA methylation is a mechanism for gene expression silencing in cancer. Limited information is available for adrenocortical tumors. Abnormal methylation at the IGF2/H19 locus is common in adrenocortical carcinomas. Our aim was to characterize the methylation in adrenocortical carcinomas at a whole-genome scale and to assess its clinical significance and its impact on gene expression.

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