Effects of Endogenous Androgens and Abdominal Fat Distribution on the Interrelationship Between Insulin and Non-Insulin-Mediated Glucose Uptake in Females | Zendy

Uche Ezeh | Zendy; Marita Pall | Zendy; Ruchi Mathur | Zendy; Damini Dey | Zendy; Daniel S. Berman | Zendy; Ida Y. Chen | Zendy; Daniel A. Dumesic | Zendy; Ricardo Azziz | Zendy

Open Access

Effects of Endogenous Androgens and Abdominal Fat Distribution on the Interrelationship Between Insulin and Non-Insulin-Mediated Glucose Uptake in Females

Author(s) -

Uche Ezeh,

Marita Pall,

Ruchi Mathur,

Damini Dey,

Daniel S. Berman,

Ida Y. Chen,

Daniel A. Dumesic,

Ricardo Azziz

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2937

Subject(s) - hyperandrogenism , endocrinology , medicine , polycystic ovary , insulin , insulin resistance , body mass index , waist , adipose tissue , waist–hip ratio

Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism and insulin resistance. Glucose disposal occurs via noninsulin-mediated glucose uptake (NIMGU) and insulin-mediated glucose uptake (IMGU). It is unknown whether in PCOS NIMGU increases to compensate for declining IMGU and whether androgens and fat distribution influence this relationship.

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