Tryptophan Hydroxylase Autoantibodies as Markers of a Distinct Autoimmune Gastrointestinal Component of Autoimmune Polyendocrine Syndrome Type 1 | Zendy

Riccardo Scarpa | Zendy; Rita Alaggio | Zendy; Lorenzo Norberto | Zendy; Jadwiga Furmaniak | Zendy; S. Chen | Zendy; Bernard Rees Smith | Zendy; Stefano Masiero | Zendy; Luca Morlin | Zendy; Mario Plebani | Zendy; F. De Luca | Zendy; Mariacarolina Salerno | Zendy; Roberta Giordano | Zendy; Giorgio Radetti | Zendy; Lucia Ghizzoni | Zendy; Giuseppe Tonini | Zendy; Fabio Farinati | Zendy; Corrado Betterle | Zendy

Open Access

Tryptophan Hydroxylase Autoantibodies as Markers of a Distinct Autoimmune Gastrointestinal Component of Autoimmune Polyendocrine Syndrome Type 1

Author(s) -

Riccardo Scarpa,

Rita Alaggio,

Lorenzo Norberto,

Jadwiga Furmaniak,

S. Chen,

Bernard Rees Smith,

Stefano Masiero,

Luca Morlin,

Mario Plebani,

F. De Luca,

Mariacarolina Salerno,

Roberta Giordano,

Giorgio Radetti,

Lucia Ghizzoni,

Giuseppe Tonini,

Fabio Farinati,

Corrado Betterle

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2734

Subject(s) - chromogranin a , medicine , gastroenterology , endocrinology , biopsy , serotonin , irritable bowel syndrome , autoantibody , pathology , immunohistochemistry , immunology , antibody , receptor

Autoantibodies to tryptophan hydroxylase (TPHAbs) directed against serotonin-producing enterochromaffin cells (EC) have been reported in autoimmune-polyendocrine-syndrome type 1 (APS-1) patients with gastrointestinal dysfunction (GID). Serotonin plays a critical role in enteric function and its peripheral blood levels reflect serotonin release from the gastrointestinal tract.

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