Low SGK1 Expression in Human Adrenocortical Tumors Is Associated with ACTH-Independent Glucocorticoid Secretion and Poor Prognosis | Zendy

Cristina L. Ronchi | Zendy; Silviu Sbiera | Zendy; Ellen Leich | Zendy; Frédérique Tissier | Zendy; Sonja Steinhauer | Zendy; Timo Deutschbein | Zendy; Martin Faßnacht | Zendy; Bruno Allolio | Zendy

Open Access

Low SGK1 Expression in Human Adrenocortical Tumors Is Associated with ACTH-Independent Glucocorticoid Secretion and Poor Prognosis

Author(s) -

Cristina L. Ronchi,

Silviu Sbiera,

Ellen Leich,

Frédérique Tissier,

Sonja Steinhauer,

Timo Deutschbein,

Martin Faßnacht,

Bruno Allolio

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2669

Subject(s) - adrenocortical carcinoma , medicine , endocrinology , protein kinase b , glucocorticoid , sgk1 , adrenocortical adenoma , biology , immunohistochemistry , cancer research , signal transduction , adenoma , biochemistry

Using single-nucleotide polymorphism analysis, we observed allelic loss of the gene for serum glucocorticoid (GC) kinase 1 (SGK1), a GC-responsive kinase involved in multiple cellular functions, in a subset of cortisol-secreting adenomas.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research