Open AccessPostprandial Total Ghrelin Suppression Is Modulated by Melanocortin Signaling in Humans
Author(s) -
Agatha A. van der Klaauw,
Julia M. Keogh,
Elana Henning,
Anthea Blackwood,
Andrea M. Haqq,
Jonathan Q. Purnell,
I. Sadaf Farooqi
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2012-2553
Subject(s) - ghrelin , postprandial , endocrinology , medicine , meal , melanocortin , melanocortin 4 receptor , biology , receptor , insulin
Ghrelin is implicated in meal initiation because circulating levels increase before and fall after meal consumption. In rodents, ghrelin stimulates food intake via hypothalamic circuits expressing the melanocortin 4 receptor (MC4R).
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