Circulating Sfrp5 Is a Signature of Obesity-Related Metabolic Disorders and Is Regulated by Glucose and Liraglutide in Humans | Zendy

Wenjing Hu | Zendy; Ling Li | Zendy; Mengliu Yang | Zendy; Xiaohe Luo | Zendy; Wenxia Ran | Zendy; Dongfang Liu | Zendy; Zhengai Xiong | Zendy; Hua Liu | Zendy; Gangyi Yang | Zendy

Open Access

Circulating Sfrp5 Is a Signature of Obesity-Related Metabolic Disorders and Is Regulated by Glucose and Liraglutide in Humans

Author(s) -

Wenjing Hu,

Ling Li,

Mengliu Yang,

Xiaohe Luo,

Wenxia Ran,

Dongfang Liu,

Zhengai Xiong,

Hua Liu,

Gangyi Yang

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2466

Subject(s) - medicine , endocrinology , insulin resistance , adiponectin , impaired glucose tolerance , type 2 diabetes , liraglutide , blood sugar regulation , body mass index , diabetes mellitus , glucose homeostasis , type 2 diabetes mellitus , glucose clamp technique , obesity , pancreatic hormone

Secreted frizzled-related protein-5 (Sfrp5) is a novel adipocyte-secreted hormone that has been shown to link obesity with diabetes. Studies in mice have revealed that Sfrp5 represents a potential target for the control of obesity-linked abnormalities in glucose homeostasis.

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