Proliferative Action of the Androgen Receptor in Human Uterine Myometrial Cells—A Key Regulator for Myometrium Phenotype Programming | Zendy

Liangliang Liu | Zendy; Yun-Qing Li | Zendy; Ning Xie | Zendy; Oksana Shynlova | Zendy; John Challis | Zendy; Donna M. Slater | Zendy; Stephen J. Lye | Zendy; Xuesen Dong | Zendy

Open Access

Proliferative Action of the Androgen Receptor in Human Uterine Myometrial Cells—A Key Regulator for Myometrium Phenotype Programming

Author(s) -

Liangliang Liu,

Yun-Qing Li,

Ning Xie,

Oksana Shynlova,

John Challis,

Donna M. Slater,

Stephen J. Lye,

Xuesen Dong

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2451

Subject(s) - regulator , myometrium , androgen receptor , key (lock) , endocrinology , action (physics) , phenotype , medicine , receptor , microbiology and biotechnology , uterus , biology , gene , genetics , prostate cancer , cancer , ecology , physics , quantum mechanics

During pregnancy, the myometrium undergoes a phenotype programming starting from an early proliferative stage, to an intermediate synthetic stage, to a late contractile stage, after which the cells commit to labor. Steroid receptors play important roles in regulating myometrial cell phenotype during pregnancy, although detailed mechanisms are not fully defined.

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