Expression of the Ring Ligase PRAJA2 in Thyroid Cancer | Zendy

Silvia Cantara | Zendy; F. DʼAngeli | Zendy; Paolo Toti | Zendy; Luca Lignitto | Zendy; Maria Grazia Castagna | Zendy; Serena Capuano | Zendy; Bellur S. Prabhakar | Zendy; Antonio Feliciello | Zendy; Furio Pacini | Zendy

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Expression of the Ring Ligase PRAJA2 in Thyroid Cancer

Author(s) -

Silvia Cantara,

F. DʼAngeli,

Paolo Toti,

Luca Lignitto,

Maria Grazia Castagna,

Serena Capuano,

Bellur S. Prabhakar,

Antonio Feliciello,

Furio Pacini

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2360

Subject(s) - anaplastic thyroid cancer , thyroid , oncogene , endocrinology , medicine , immunohistochemistry , thyroid cancer , thyroid hormone receptor beta , messenger rna , biology , cancer research , cancer , western blot , hormone receptor , cell cycle , gene , breast cancer , biochemistry

In thyroid cells, binding of TSH to its receptor increases cAMP levels, sustaining thyrocytes growth and hormone production. The main cAMP effector enzyme is protein kinase A (PKA). Praja2 is a widely expressed RING (Really Interesting New Gene) ligase, which degrades the regulatory subunits of PKA, thus controlling the strength and duration of PKA signaling in response to cAMP. Differentiated thyroid cancer expresses a functional TSH receptor, and its growth and progression are positively regulated by TSH and cAMP signaling.

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