Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men | Zendy

Johan Svensson | Zendy; Daniel Carlzon | Zendy; Max Petzold | Zendy; Magnus K. Karlsson | Zendy; Östen Ljunggren | Zendy; Åsa Tivesten | Zendy; Dan Mellström | Zendy; Claes Ohlsson | Zendy

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Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men

Author(s) -

Johan Svensson,

Daniel Carlzon,

Max Petzold,

Magnus K. Karlsson,

Östen Ljunggren,

Åsa Tivesten,

Dan Mellström,

Claes Ohlsson

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2329

Subject(s) - medicine , hazard ratio , proportional hazards model , confidence interval , population , prospective cohort study , cancer , demography , endocrinology , environmental health , sociology

Although recent population-based studies suggest a U-shaped relationship between serum IGF-I concentration and all-cause mortality, the distribution of death causes underlying this association remains unclear. We hypothesized that high IGF-I levels associate with increased cancer mortality, whereas low IGF-I levels associate with increased cardiovascular disease (CVD) mortality.

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