Cerebrospinal Fluid Levels of Leptin, Proopiomelanocortin, and Agouti-Related Protein in Human Pregnancy: Evidence for Leptin Resistance | Zendy

Gabrielle PageWilson | Zendy; Elena Reitman-Ivashkov | Zendy; Kana Meece | Zendy; Anne White | Zendy; Michael Rosenbaum | Zendy; Richard M. Smiley | Zendy; Sharon L. Wardlaw | Zendy

Open Access

Cerebrospinal Fluid Levels of Leptin, Proopiomelanocortin, and Agouti-Related Protein in Human Pregnancy: Evidence for Leptin Resistance

Author(s) -

Gabrielle PageWilson,

Elena Reitman-Ivashkov,

Kana Meece,

Anne White,

Michael Rosenbaum,

Richard M. Smiley,

Sharon L. Wardlaw

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2309

Subject(s) - leptin , medicine , endocrinology , proopiomelanocortin , cerebrospinal fluid , leptin receptor , appetite , pregnancy , body mass index , hypothalamus , obesity , biology , genetics

Leptin suppresses appetite by modulating the expression of hypothalamic neuropeptides including proopiomelanocortin (POMC) and agouti-related peptide (AgRP). Yet during pregnancy, caloric consumption increases despite elevated plasma leptin levels.

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