Open AccessEstradiol, Tamoxifen, and Flaxseed Alter IL-1β and IL-1Ra Levels in Normal Human Breast Tissue in Vivo
Author(s) -
Annelie Abrahamsson,
Vivian Morad,
Niina Saarinen,
Charlotta Dabrosin
Publication year - 2012
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2012-2288
Subject(s) - breast cancer , tamoxifen , medicine , endocrinology , antiestrogen , estrogen , mammary gland , proinflammatory cytokine , cancer , inflammation
Sex steroid exposure increases the risk of breast cancer by unclear mechanisms. Diet modifications may be one breast cancer prevention strategy. The proinflammatory cytokine family of IL-1 is implicated in cancer progression. IL-1Ra is an endogenous inhibitor of the proinflammatory IL-1α and IL-1β.
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