Circulating IgGs May Modulate IGF-I Receptor Stimulating Activity in a Subset of Patients With Graves' Ophthalmopathy | Zendy

Aimee J. Varewijck | Zendy; Anita Boelen | Zendy; Steven W. J. Lamberts | Zendy; Eric Fliers | Zendy; Leo J. Hofland | Zendy; Wilmar M. Wiersinga | Zendy; J. A. M. J. L. Janssen | Zendy

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Circulating IgGs May Modulate IGF-I Receptor Stimulating Activity in a Subset of Patients With Graves' Ophthalmopathy

Author(s) -

Aimee J. Varewijck,

Anita Boelen,

Steven W. J. Lamberts,

Eric Fliers,

Leo J. Hofland,

Wilmar M. Wiersinga,

J. A. M. J. L. Janssen

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2270

Subject(s) - medicine , endocrinology , subclinical infection , euthyroid , thyrotropin receptor , receptor , graves' disease , graves' ophthalmopathy , thyroid

There is a close association between levels of TSH binding inhibitory immunoglobulins (TBIIs) and Graves' ophthalmopathy (GO). In addition to the TSH receptor, the IGF-I receptor (IGF-IR) has been proposed to be a second autoantigen that plays a role in the pathogenesis of GO.

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