Effect of Tight Glucose Control with Insulin on the Thyroid Axis of Critically Ill Children and Its Relation with Outcome | Zendy

Marijke Gielen | Zendy; Dieter Mesotten | Zendy; Pieter Wouters | Zendy; Lars Desmet | Zendy; Dirk Vlasselaers | Zendy; Ilse Vanhorebeek | Zendy; Lies Langouche | Zendy; Greet Van den Berghe | Zendy

Open Access

Effect of Tight Glucose Control with Insulin on the Thyroid Axis of Critically Ill Children and Its Relation with Outcome

Author(s) -

Marijke Gielen,

Dieter Mesotten,

Pieter Wouters,

Lars Desmet,

Dirk Vlasselaers,

Ilse Vanhorebeek,

Lies Langouche,

Greet Van den Berghe

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2240

Subject(s) - critically ill , medicine , outcome (game theory) , insulin , relation (database) , pediatrics , endocrinology , intensive care medicine , mathematics , computer science , data mining , mathematical economics

Tight glucose control (TGC) to normal-for-age fasting blood glucose levels reduced morbidity and mortality in surgical adult and pediatric intensive care unit (ICU) patients. In adults, TGC did not affect the illness-induced alterations in thyroid hormones. With better feeding in children than in adult patients, we hypothesized that TGC in pediatric ICU patients reactivates the thyroid axis.

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