Intermedin/Adrenomedullin 2 Is Associated With Implantation and Placentation via Trophoblast Invasion in Human Pregnancy | Zendy

Dara Havemann | Zendy; Meena Balakrishnan | Zendy; Mostafa A. Borahay | Zendy; Regan N. Theiler | Zendy; Kristofer Jennings | Zendy; Janice J. Endsley | Zendy; John Y. Phelps | Zendy; Gary D.V. Hankins | Zendy; Chandra Yallampalli | Zendy; Madhu Chauhan | Zendy

Open Access

Intermedin/Adrenomedullin 2 Is Associated With Implantation and Placentation via Trophoblast Invasion in Human Pregnancy

Author(s) -

Dara Havemann,

Meena Balakrishnan,

Mostafa A. Borahay,

Regan N. Theiler,

Kristofer Jennings,

Janice J. Endsley,

John Y. Phelps,

Gary D.V. Hankins,

Chandra Yallampalli,

Madhu Chauhan

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2172

Subject(s) - placentation , cytotrophoblast , trophoblast , decidua , biology , placenta , pregnancy , endocrinology , decidual cells , andrology , medicine , adrenomedullin , gestation , fetus , receptor , genetics

Intermedin (IMD) is a novel peptide expressed in trophoblast cells in human placenta and enhances the invasion, migration, and human leukocyte antigen class I, G (HLA-G) expression in first-trimester HTR-8SV/neo cells. We recently reported that infusion of IMD antagonist in pregnant rats is detrimental to pregnancy outcome, resulting in impaired fetoplacental growth and deformed placental vasculature.

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