High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet | Zendy

Günther Silbernagel | Zendy; Markéta Kovářová | Zendy; Alexander Čegan | Zendy; Jürgen Machann | Zendy; Fritz Schick | Zendy; Rainer Lehmann | Zendy; HansUlrich Häring | Zendy; Norbert Stefan | Zendy; Erwin Schleicher | Zendy; Andreas Fritsche | Zendy; Andreas Peter | Zendy

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High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet

Author(s) -

Günther Silbernagel,

Markéta Kovářová,

Alexander Čegan,

Jürgen Machann,

Fritz Schick,

Rainer Lehmann,

HansUlrich Häring,

Norbert Stefan,

Erwin Schleicher,

Andreas Fritsche,

Andreas Peter

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-2152

Subject(s) - lipogenesis , medicine , endocrinology , fatty liver , fatty acid , chemistry , fatty acid synthase , monosaccharide , sugar , metabolism , lipid metabolism , food science , biochemistry , disease

Increased hepatic de novo lipogenesis (DNL) in response to dietary sugar is implicated in the pathophysiology of fatty liver. Saturated fatty acids are the product of DNL and exert lipotoxic effects that promote liver fat accumulation. Desaturation of fatty acids by stearoyl-CoA desaturase 1 (SCD1) can prevent these deleterious effects. Here we investigated whether DNL and SCD1 are activated in parallel by dietary sugar and influence liver fat accumulation.

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