PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome | Zendy

Xin He | Zendy; Motoyasu Saji | Zendy; Deepa Radhakrishnan | Zendy; Todd Romigh | Zendy; Joanne Ngeow | Zendy; Qi Yu | Zendy; Yu Wang | Zendy; Matthew D. Ringel | Zendy; Charis Eng | Zendy

Open Access

PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome

Author(s) -

Xin He,

Motoyasu Saji,

Deepa Radhakrishnan,

Todd Romigh,

Joanne Ngeow,

Qi Yu,

Yu Wang,

Matthew D. Ringel,

Charis Eng

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-1991

Subject(s) - pten , cowden syndrome , tensin , protein kinase b , cancer research , pi3k/akt/mtor pathway , thyroid cancer , thyroid , medicine , endocrinology , biology , pathology , phosphorylation , signal transduction , microbiology and biotechnology

Germline mutations in PTEN are associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) hamartoma tumor syndrome including Cowden syndrome (CS) and Cowden-like syndrome (CSL) that predisposes to high risks of benign and malignant tumors of thyroid and breast.

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