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Impact of Antenatal Synthetic Glucocorticoid Exposure on Endocrine Stress Reactivity in Term-Born Children
Author(s) -
Nina Alexander,
Franziska Rosenlöcher,
Tobias Stalder,
Julia Linke,
W. Distler,
J Morgner,
Clemens Kirschbaum
Publication year - 2012
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2012-1970
Subject(s) - glucocorticoid , trier social stress test , offspring , endocrinology , medicine , stressor , endocrine system , psychosocial , dexamethasone , hormone , pregnancy , physiology , biology , psychiatry , fight or flight response , biochemistry , genetics , gene
Antenatal glucocorticoid (GC) exposure has been discussed as a potent programming factor of hypothalamus-pituitary-adrenal (HPA) axis activity, producing sustained alterations in cortisol secretion throughout life. So far, the assessment of HPA-axis activity in offspring of mothers treated with synthetic GC has been limited to a time period shortly after birth, with prematurity being an important confound in most prior studies.

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