Measurements of Serum DHEA and DHEA Sulphate Levels Improve the Accuracy of the Low-Dose Cosyntropin Test in the Diagnosis of Central Adrenal Insufficiency | Zendy

Laure Sayyed Kassem | Zendy; Katia El Sibai | Zendy; Joumana Chaiban | Zendy; Dima Abdelmannan | Zendy; Baha M. Arafah | Zendy

Open Access

Measurements of Serum DHEA and DHEA Sulphate Levels Improve the Accuracy of the Low-Dose Cosyntropin Test in the Diagnosis of Central Adrenal Insufficiency

Author(s) -

Laure Sayyed Kassem,

Katia El Sibai,

Joumana Chaiban,

Dima Abdelmannan,

Baha M. Arafah

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-1806

Subject(s) - cosyntropin , dehydroepiandrosterone , dehydroepiandrosterone sulfate , medicine , adrenal insufficiency , endocrinology , stimulation , hydrocortisone , acth stimulation test , adrenocorticotropic hormone , hormone , androgen

The diagnosis of central adrenal insufficiency (AI) continues to be challenging, especially when it is partial. We have recently demonstrated the value of measuring serum dehydroepiandrosterone sulfate (DHEA-S) in establishing the diagnosis of central AI. The current investigation examined the added value of measuring serum dehydroepiandrosterone (DHEA) levels during low-dose (1 μg) cosyntropin (LDC) stimulation in patients suspected to have central AI.

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