Increased Tenascin C And Toll-Like Receptor 4 Levels in Visceral Adipose Tissue as a Link between Inflammation and Extracellular Matrix Remodeling in Obesity
Author(s) -
Victoria Catalán,
Javier GómezAmbrosi,
Amaia Rodrı́guez,
Beatriz Ramírez,
Fernando Rotellar,
Víctor Valentí,
Camilo Silva,
Marı́a J. Gil,
Javier Salvador,
Gema Frühbeck
Publication year - 2012
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2012-1670
Subject(s) - adipose tissue , inflammation , medicine , endocrinology , proinflammatory cytokine , extracellular matrix , tlr4 , adipose tissue macrophages , tenascin c , stromal vascular fraction , adipocyte , mmp9 , white adipose tissue , biology , microbiology and biotechnology , downregulation and upregulation , biochemistry , gene
Obesity is associated with an altered inflammatory and extracellular matrix (ECM) profile. Tenascin C (TNC) is an ECM glycoprotein with proinflammatory effects.
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