Secretion Patterns of Circulating Osteoprotegerin and Response to Acute and Chronic Energy Deprivation in Young Healthy Adults | Zendy

Konstantinos N. Aronis | Zendy; JooPin Foo | Zendy; John P. Chamberland | Zendy; Christos S. Mantzoros | Zendy

Open Access

Secretion Patterns of Circulating Osteoprotegerin and Response to Acute and Chronic Energy Deprivation in Young Healthy Adults

Author(s) -

Konstantinos N. Aronis,

JooPin Foo,

John P. Chamberland,

Christos S. Mantzoros

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-1618

Subject(s) - medicine , endocrinology , osteoprotegerin , leptin , placebo , sexual dimorphism , obesity , receptor , activator (genetics) , alternative medicine , pathology

Osteoprotegerin (OPGN) is a bone-remodeling marker that is associated with various metabolic and vascular complications. Cross-sectional studies in humans have demonstrated an inverse association between leptin, a marker of energy sufficiency, and OPGN. The physiology of OPGN has not been fully elucidated to date. We thus aim to elucidate 1) whether OPGN levels exhibit any gender dimorphism or day/night secretion pattern; and 2) whether there is any effect of acute and/or chronic energy deprivation on its circulating levels and whether such effects are mediated through leptin.

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