Association of FOXE1 Polyalanine Repeat Region with Papillary Thyroid Cancer | Zendy

Martyn Bullock | Zendy; Emma L. Duncan | Zendy; Christine J. O’Neill | Zendy; Lyndal Tacon | Zendy; Mark Sywak | Zendy; Stan B. Sidhu | Zendy; Leigh Delbridge | Zendy; Diana Learoyd | Zendy; Bruce G. Robinson | Zendy; Marian Ludgate | Zendy; Roderick CliftonBligh | Zendy

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Association of FOXE1 Polyalanine Repeat Region with Papillary Thyroid Cancer

Author(s) -

Martyn Bullock,

Emma L. Duncan,

Christine J. O’Neill,

Lyndal Tacon,

Mark Sywak,

Stan B. Sidhu,

Leigh Delbridge,

Diana Learoyd,

Bruce G. Robinson,

Marian Ludgate,

Roderick CliftonBligh

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-1456

Subject(s) - linkage disequilibrium , single nucleotide polymorphism , biology , medicine , genetics , genotype , gene

Polyalanine tract variations in transcription factors have been identified for a wide spectrum of developmental disorders. The thyroid transcription factor forkhead factor E1 (FOXE1) contains a polymorphic polyalanine tract with 12-22 alanines. Single-nucleotide polymorphisms (SNP) close to this locus are associated with papillary thyroid cancer (PTC), and a strong linkage disequilibrium block extends across this region.

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