Metabolic Activity in the Insular Cortex and Hypothalamus Predicts Hot Flashes: An FDG-PET Study | Zendy

Hadine Joffe | Zendy; Thilo Deckersbach | Zendy; Nancy U. Lin | Zendy; Nikos Makris | Zendy; Todd C. Skaar | Zendy; Scott L. Rauch | Zendy; Darin D. Dougherty | Zendy; Janet E. Hall | Zendy

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Metabolic Activity in the Insular Cortex and Hypothalamus Predicts Hot Flashes: An FDG-PET Study

Author(s) -

Hadine Joffe,

Thilo Deckersbach,

Nancy U. Lin,

Nikos Makris,

Todd C. Skaar,

Scott L. Rauch,

Darin D. Dougherty,

Janet E. Hall

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-1413

Subject(s) - insular cortex , hypothalamus , medicine , metabolic activity , cortex (anatomy) , neuroscience , endocrinology , psychology , physiology

Hot flashes are a common side effect of adjuvant endocrine therapies (AET; leuprolide, tamoxifen, aromatase inhibitors) that reduce quality of life and treatment adherence in breast cancer patients. Because hot flashes affect only some women, preexisting neurobiological traits might predispose to their development. Previous studies have implicated the insula during the perception of hot flashes and the hypothalamus in thermoregulatory dysfunction.

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