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The pathogenesis of isolated hypoparathyroidism, also referred to as idiopathic hypoparathyroidism (IH), is not clear. There is a paucity of information related to the immunogenetic basis of the disease due to its rarity. A recurrent theme of several autoimmune disorders is aberrant antigen presentation.

Presence of Strong Association of the Major Histocompatibility Complex (MHC) Class I AlleleHLA-A*26:01with Idiopathic Hypoparathyroidism

Presence of Strong Association of the Major Histocompatibility Complex (MHC) Class I AlleleHLA-A**26:01*with Idiopathic Hypoparathyroidism