SomaticGNASMutation Causes Widespread and Diffuse Pituitary Disease in Acromegalic Patients with McCune-Albright Syndrome | Zendy

Alexander O. Vortmeyer | Zendy; Sven Gläsker | Zendy; Gautam U. Mehta | Zendy; Mones AbuAsab | Zendy; Jonathan H. Smith | Zendy; Zhengping Zhuang | Zendy; Michael T. Collins | Zendy; Edward H. Oldfield | Zendy

Open Access

SomaticGNASMutation Causes Widespread and Diffuse Pituitary Disease in Acromegalic Patients with McCune-Albright Syndrome

Author(s) -

Alexander O. Vortmeyer,

Sven Gläsker,

Gautam U. Mehta,

Mones AbuAsab,

Jonathan H. Smith,

Zhengping Zhuang,

Michael T. Collins,

Edward H. Oldfield

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-1274

Subject(s) - gnas complex locus , acromegaly , medicine , somatotropic cell , mccune–albright syndrome , pituitary gland , adenoma , pituitary adenoma , pathology , hyperplasia , pituitary tumors , endocrinology , hormone , biology , growth hormone , precocious puberty , biochemistry , gene

McCune-Albright syndrome (MAS) is caused by sporadic mutations of the GNAS. Patients exhibit features of acromegaly. In most patients, GH-secreting pituitary adenomas have been held responsible for this presentation. However, surgical adenomectomy rarely eliminates excess GH production.

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