Decreased Lectin-Like Oxidized LDL Receptor 1 (LOX-1) and Low Nrf2 Activation in Placenta Are Involved in Preeclampsia | Zendy

Yoshitsugu Chigusa | Zendy; Keiji Tatsumi | Zendy; Eiji Kondoh | Zendy; Kohei Fujita | Zendy; Fumitomo Nishimura | Zendy; Haruta Mogami | Zendy; Ikuo Konishi | Zendy

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Decreased Lectin-Like Oxidized LDL Receptor 1 (LOX-1) and Low Nrf2 Activation in Placenta Are Involved in Preeclampsia

Author(s) -

Yoshitsugu Chigusa,

Keiji Tatsumi,

Eiji Kondoh,

Kohei Fujita,

Fumitomo Nishimura,

Haruta Mogami,

Ikuo Konishi

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-1268

Subject(s) - preeclampsia , placenta , medicine , endocrinology , scavenger receptor , receptor , chemistry , activator (genetics) , biology , andrology , fetus , lipoprotein , cholesterol , pregnancy , genetics

Serum concentration of oxidized low-density lipoprotein (oxLDL) is higher in women with preeclampsia than in normal pregnant woman. Lectin-like oxLDL receptor-1 (LOX-1) is one of the scavenger receptors for oxLDL and is abundantly expressed in placenta. It is well known that oxLDL activates nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant and cytoprotective genes such as heme oxygenase-1 (HO-1), which play an important role in preeclampsia. However, it has yet to be elucidated whether LOX-1, along with Nrf2, participates in the pathology of preeclampsia.

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