Mechanisms for the Antihyperglycemic Effect of Sitagliptin in Patients with Type 2 Diabetes
Author(s) -
Elza Muscelli,
A Casolaro,
Amalia Gastaldelli,
Andrea Mari,
Giuseppe Seghieri,
Brenno Astiarraga,
Yu Chen,
Maria Alba,
Jens J. Holst,
Ele Ferrannini
Publication year - 2012
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2012-1205
Subject(s) - medicine , incretin , sitagliptin , endocrinology , type 2 diabetes , glycemic , insulin , area under the curve , diabetes mellitus , glycated hemoglobin , context (archaeology) , placebo , glucagon , meal , glucagon like peptide 1 , biology , paleontology , alternative medicine , pathology
Dipeptidyl peptidase IV (DPP-4) inhibitors improve glycemic control in patients with type 2 diabetes. The underlying mechanisms (incretin effect, β-cell function, endogenous glucose production) are not well known.
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