SNP Array Profiling of Childhood Adrenocortical Tumors Reveals Distinct Pathways of Tumorigenesis and Highlights Candidate Driver Genes | Zendy

Éric Letouzé | Zendy; Roberto Rosati | Zendy; Heloísa Komechen | Zendy; Mabrouka Doghman | Zendy; Laëtitia Marisa | Zendy; Christa E. Flück | Zendy; Ronald R. de Krijger | Zendy; Max M. van Noesel | Zendy; Jean-Christophe Mas | Zendy; Mara Albonei Dudeque Pianovski | Zendy; Gerard P. Zambetti | Zendy; Bonald C. Figueiredo | Zendy; Enzo Lalli | Zendy

Open Access

SNP Array Profiling of Childhood Adrenocortical Tumors Reveals Distinct Pathways of Tumorigenesis and Highlights Candidate Driver Genes

Author(s) -

Éric Letouzé,

Roberto Rosati,

Heloísa Komechen,

Mabrouka Doghman,

Laëtitia Marisa,

Christa E. Flück,

Ronald R. de Krijger,

Max M. van Noesel,

Jean-Christophe Mas,

Mara Albonei Dudeque Pianovski,

Gerard P. Zambetti,

Bonald C. Figueiredo,

Enzo Lalli

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-1184

Subject(s) - loss of heterozygosity , biology , carcinogenesis , cancer research , comparative genomic hybridization , genetics , gene , copy number variation , snp , single nucleotide polymorphism , tumor suppressor gene , candidate gene , mdm2 , chromosome , genotype , allele , genome

Childhood adrenocortical tumors (ACT) are rare malignancies, except in southern Brazil, where a higher incidence rate is associated to a high frequency of the founder R337H TP53 mutation. To date, copy number alterations in these tumors have only been analyzed by low-resolution comparative genomic hybridization.

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